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Patients were randomly assigned to receive placebo or 25 mg of spironolactone daily in addition to their current regimen. Patients taking beta-blockers or other negative chronotropic agents that would inhibit the ability to achieve an adequate heart rate response to exercise are also appropriate candidates for vasodilator stress.

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This type of exercise may be performed on a treadmill or bicycle and increases flow demand, which secondarily increases flow. Aggrenox